![]() This containment turns off the drugs' biological effects, said Isaacs.Īdditional work showed that P6AS can bind to many other drugs including MDMA, PCP, and mephedrone. Tests conducted in the lab and in animal models indicated that P6AS can sequester fentanyl and methamphetamine, which mitigates their effects. The compound is a molecular container that can attach to other chemicals and sequester them inside of a cavity. ![]() “That’s one of the huge opportunities for our compound.” “Opioids already have a reversal agent in naloxone, but there are a variety of non-opioid drugs of abuse like methamphetamine, PCP, mephedrone, ecstasy (MDMA) and cocaine that do not have a specific antidote,” said lead study author Lyle Isaacs, a professor at University of Maryland (UMD). Reporting in the journal Chem, scientists have shown that it could be used as an antidote for fentanyl and methamphetamine overdoses, and potentially counters other drugs as well. Scientists have now developed a more universal treatment that can counter the effects of drug overdoses, a compound called PillarMaxQ (P6AS). There is a drug called naloxone, which is sold as Narcan that can prevent opioid overdoses, and has already saved many lives. Deaths from synthetic opioids like fentanyl are increasing dramatically, while overdoses from other types of drugs have remained relatively steady. About 92,000 people died from drug and prescription opioid overdoses in 2020. Of course this is the other extreme from standing still, so in an actual gameplay situation, with more stop-start movement, survivability would be increased.Drug overdose deaths continue to rise in the United States. Testing in a 100 LBP zone, with Detox reapplied as needed, no power left for the Environment suit, and the player running around constantly, lifetime is not meaningfully extended past the ~75 seconds in which the zone would kill the player normally. As the player moves from tile to tile in a hot zone, the set contamination level is reapplied. However, a player would realistically be moving around in a hot zone as as to achieve their purpose for being there and get out quickly. In this scenario, the player will take less damage and survive a while longer, perhaps because some of the damage ticks striking when the player is at a reduced contamination level. ![]() Standing in a contaminated tile with Detox applied (and reapplied as needed) will periodically reduce the contamination level temporarily, though it will sometimes go back to full. Radioactive and/or biological contamination levels will be rapidly reduced if the player has left the "hot" zone, thus negating most of the damage the player would have taken if they had let the contamination fade away normally. Use the Biological Systems Monitor to see when the patch has worn off. Notably this makes healing with Medipatches nearly worthless, but a First-Aid Kit will not be affected due to its non-pharmaceutical nature.Īs such, it is best not to use Detox if you need to use any other patches in the immediate future, such as in combat. The exception to this is the full fatigue side effect of Staminup, which is not reduced or shortened. While Detox is active, the primary effects of current or new patches will be nullified within a couple seconds, and any side effects will then be applied and subsequently nullified just as quickly. From limited testing, this duration varies from ~43 to ~73 seconds. The Detox will remain in your system for a short while. The acting compounds are still being tested and show serious side effects with their current compositions. The method of application is a dermal patch applied directly to the skin, with the dose delivered by dermal osmosis. An experimental combat-enhancement patch developed by TriOptimum Pharmaceutical in the 2070's, it counters the effects of toxins and bio-hazards and, to date, removes side effects of other patches.
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